| Project description
The company which submitted the application, Carmeda AB, is a company focussing
on blood compatible surfaces. The technology, which is known under the name
of CBAS™ (Carmeda Bioactive Surface), is now well-established, and used in a
number of bloodrelated products. The technology is based on a unique mechanism
to link heparin molecules to a surface, keeping the clotting prohibiting
properties of the molecules intact. The heparin molecules can be linked to a
large number of substrates like e.g. thermoplastics and metals.
The purpose of the project was to get a deeper understanding of the relation
between molecular surface composition and biological function of heparin
surfaces, and also to obtain an increased understanding of how secondary ion
mass spectroscopy, measured with TOF-SIMS, reflects the molecular composition
and structure of complex surfaces. The collaborating research partner was SP
in Borås, also a partner in the project “Tribology of Articulating Joints”.
Helena Franzén at Carmeda says:
”Generally speaking, we believe that an exchange of knowledge, as represented
by this project, is of great value for both parties, since we benefit from each
others competence and resources. It is also of great value that we together,
because of differences in background, can get new ideas how to approach the
scientific questions we are working with. Another important issue is that a
small company like Carmeda does not have the possibility to in-house have all
the competence or all the scientific instruments needed, like e.g. the
ToF-SIMS instrument at SP that is used in this project. It is of great value
for us to have access to resources in this way. Further, we hope that this
cooperation will lead to further exchange of knowledge in the future, to the
benefit for both parties.”
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