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ToF-SIMS-analysis of complex surface modifications
QCM-D based characterization of lipid-based sensor templates developed for SPR analysis
Preparation, characterization and immune system activation in blood by new conducting electrode materials in pacemaker applications
Soft- and bone tissue reactions on loaded microimplants with different surface modifications
Interaction of antithrombin with different types of heparin surfaces with implications for cellular interactions
ToF-SIMS-analysis of complex surface modifications  
Biocompatible Materials » Project survey » Projects in cooperation with industries » ToF-SIMS-analysis of complex surface modifications
Project description
 
The company which submitted the application, Carmeda AB, is a company focussing on blood compatible surfaces. The technology, which is known under the name of CBAS™ (Carmeda Bioactive Surface), is now well-established, and used in a number of bloodrelated products. The technology is based on a unique mechanism to link heparin molecules to a surface, keeping the clotting prohibiting properties of the molecules intact. The heparin molecules can be linked to a large number of substrates like e.g. thermoplastics and metals.

The purpose of the project was to get a deeper understanding of the relation between molecular surface composition and biological function of heparin surfaces, and also to obtain an increased understanding of how secondary ion mass spectroscopy, measured with TOF-SIMS, reflects the molecular composition and structure of complex surfaces. The collaborating research partner was SP in Borås, also a partner in the project “Tribology of Articulating Joints”.

Helena Franzén at Carmeda says: ”Generally speaking, we believe that an exchange of knowledge, as represented by this project, is of great value for both parties, since we benefit from each others competence and resources. It is also of great value that we together, because of differences in background, can get new ideas how to approach the scientific questions we are working with. Another important issue is that a small company like Carmeda does not have the possibility to in-house have all the competence or all the scientific instruments needed, like e.g. the ToF-SIMS instrument at SP that is used in this project. It is of great value for us to have access to resources in this way. Further, we hope that this cooperation will lead to further exchange of knowledge in the future, to the benefit for both parties.”

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