| Background and description
One of the main problems with orthopaedic implants is the formation of wear
particles, which cause osteolysis that leads to bone resorption and eventually
implant loosening. Wear is influenced by a number of factors, e.g. the bearing
combination, wear particle access and joint fluid pressure.
This project addressed the problem of wear in artificial joints (primarily
knee and hip joints) from several different directions. It contained the
following main ingredients: (i) tribological studies and development of wear
testing protocols, (ii) exploration of interesting existing candidate materials,
as well as development of new modified ma-terials, (iii) studies of retrieved
clinical materials (donor programme), and (iv) clinical follow-up (national
registers). The tribological studies were performed at the Swedish National
Testing and Research Institute (SP) and included the following main parts:
(i) basic model experiments where the material properties and experimental
conditions were systematically varied in order to obtain general knowledge
about the tribological system, (ii) development of wear testing protocols
for screening of material combinations, and (iii) studies of materials
developed within the project or by external collaborators.
Scientific results
A new screening method was developed for tribological investigation of joint
implants. The testing period could be drastically reduced using a pin-on-disc
method compared to a relatively long testing period (6-10 weeks) using a
multiaxial joint wear simulator. For studying the amount of wear in a hip
joint, radiostereophotogrammetry and X-ray single plane photogrammetric
analyses were used. It was shown that a 32 mm femoral head had three times
higher volume of wear particles compared to a 22 mm head. There was also a
clear connection between the amount of fluid in the joint capsule measured
with ultrasound with clear correlation to wear and clinical loosening.
In order to reduce wear of joint couplings, both the metal and polymer
parts have been studied in the project. The present sterilization treatment
of UHMWPE using gamma irradiation gives a deterioration of the mechanical
properties along with increased levels of oxidation. Different types of
annealing treatment were tested and it was shown that high temperature
annealing reduced wear. Addition of a radical scavenger to PE reduced the
amount of free radicals and oxidation.
A model for carbon nitride coating of orthopaedic bearing substrates
(Si, Ti and ZrO2) was developed in collaboration between Dept.
of Biomaterials, GU, and Thin Film Physics Division, Dept. of Physics, LiU.
The coating, which consists of a “fullerene-like” microstructure with curved,
frequently intersecting and highly in-plane oriented basal lattice planes,
has promising properties for further development in order to reduce
friction and generation of wear particles in orthopaedic artificial joint
bearings.
Four Ph.D. theses have been presented in the program.and one licentiate
thesis.
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